Virucidal Activity of Virkon 5 on Human Enterovirus 71
نویسنده
چکیده
Enterovirus 71 (HEV7l) is a non-enveloped, single stranded positive sense RNA virus belonging to the genus Enterovirus of the Picornaviridae family. HEV71 is an important causative agent of hand, foot and mouth disease (HFMD) worldwide affecting millions of young children annually'. The pathogenesis of HEV71 infection however, is not well established. It is not known for example why the infection caused many deaths in outbreaks in Malaysia' and Taiwan' as the virus had caused infections elsewhere but with few deaths if any. Nonetheless, it is known that the virus is transmitted through faecal-oral route and also through direct contact with infected persons secretions'. The lack of proper hygienic care and close contacts between children has been attributed as one of the possible means by which the infection may spread. The fear that young children could acquire the infection through direct contact while in close contact with peers had previously resulted in nationwide closure of kindergartens, playgrounds, swimming pools and schools. These had severely disrupted the life of millions and caused severe economic impact on the country'. As such effective measures for the immediate containment of the infection and potential future outbreaks are highly desirable. Apart from good sanitation and hygienic practices, effective disinfection strategies are also necessary.
منابع مشابه
Broad-spectrum virucidal activity of (NVC-422) N,N-dichloro-2,2-dimethyltaurine against viral ocular pathogens in vitro.
PURPOSE Viral conjunctivitis is a highly contagious infection often causing major epidemics. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need. The purpose of this study is to demonstrate that in vitro NVC-422 is a safe, broad-spectrum topical virucidal agent with activity against ophthalmic viral pathogens. METHODS The virucidal activity of NVC-422 against seve...
متن کاملThe Antiviral Effect of Baicalin on Enterovirus 71 In Vitro
Baicalin is a flavonoid compound extracted from Scutellaria roots that has been reported to possess antibacterial, anti-inflammatory, and antiviral activities. However, the antiviral effect of baicalin on enterovirus 71 (EV71) is still unknown. In this study, we found that baicalin showed inhibitory activity on EV71 infection and was independent of direct virucidal or prophylactic effect and in...
متن کاملInactivation of an enterovirus by airborne disinfectants
BACKGROUND The activity of airborne disinfectants on bacteria, fungi and spores has been reported. However, the issue of the virucidal effect of disinfectants spread by fogging has not been studied thoroughly. METHODS A procedure has been developed to determine the virucidal activity of peracetic acid-based airborne disinfectants on a resistant non-enveloped virus poliovirus type 1. This viru...
متن کاملInhibition of Enterovirus 71 (EV-71) Infections by a Novel Antiviral Peptide Derived from EV-71 Capsid Protein VP1
Enterovirus 71 (EV-71) is the main causative agent of hand, foot and mouth disease (HFMD). In recent years, EV-71 infections were reported to cause high fatalities and severe neurological complications in Asia. Currently, no effective antiviral or vaccine is available to treat or prevent EV-71 infection. In this study, we have discovered a synthetic peptide which could be developed as a potenti...
متن کامل